The Tournament

A protein engineering competition employing high-throughput automation to determine the winner by experimentation.

THE PROTEIN ENGINEERING TOURNAMENT

The Tournament provides a transparent platform for fostering collaboration, evaluating progress, and establishing benchmarks in the field. 

The Protein Engineering Tournament fosters advances in AI x Bio and evolves upon classic protein design competitions by employing high-throughput automation to determine the Tournament winner by experimentation. The Tournament empowers computational scientists to move beyond the confines of the dry lab to benchmark their protein design techniques in silico and in vitro.

During the Tournament, participants use protein function datasets to progress from predicting properties to designing proteins. Automated methods are developed to generate datasets for the competition and evaluate the final protein designs, selecting the winners through experimentation. This cycle generates open-source, dynamic datasets and standardized, automated protocols for the community for continued benchmarking by future teams.

The 2023 pilot Protein Engineering Tournament results are out.

Click here to see them!

Watch now!

Our 2023 pilot Tournament teams discuss their experience and the future of machine learning models for protein function prediction!

Click here to watch

HIGHLIGHTS FROM THE 2023 PILOT TOURNAMENT

7

final teams, including: 3 academic, 2 industry, and 2 mixed teams

85

users registered to access the data across 28 teams

>40,000

datapoints across
all of our datasets

6

donated datasets from 2 industry and 4 academic groups

1200

unique protein sequences submitted for in vitro characterization

CURRENT RESEARCH OUTCOMES

How does the Tournament work?

The Tournament consists of two rounds, the in silico, and in vitro.


(A) in silico round

Participants predict properties of given protein sequences, with optional training data provided for specific events. Performance is evaluated by comparing the participant’s predictions with the ground-truth values. Top performing participants are selected to advance to the in vitro round.


(B) in vitro round

Participants are asked to generate protein sequences based on desired properties, which are then be expressed and characterized in vitro. Performance of the designed sequences are evaluated as a weighted combination of the protein’s properties; the exact evaluation metric will be event-dependent.

Powered by Community Leadership

  • Mohamed Hassan Kane

    Medium Biosciences

  • Dave Estell

    International Flavors & Fragrances

  • Chase Armer

    Columbia University

  • Adil Yusuf

    Medium Biosciences

  • Henning Redestig

    International Flavors & Fragrances

  • Dana Cortade

    Align to Innovate

  • TJ Brunette

    Align to Innovate

  • Pete Kelly

    Align to Innovate

How can I get involved?

I would like to participate in the next Tournament !

We invite academic, industry, and mixed teams to participate, from anywhere around the world!

Sign up as a team of one or with your lab mates or colleagues.

I would like to contribute a dataset to the Tournament!

Academic and industry groups are invited to sponsor Tournament ‘Events’ by providing datasets and their associated challenge problems.

I would like to organize the next Tournament!

Our Planning Committee is open to new members! The planning committee works with Align to Innovate to coordinate, judge, and plan upcoming Tournaments.

Contact us at at tournament@alignbio.org

Sign up here to hear about the next Tournament.

Resources


Frequently Asked Questions

  • Participation in Round 1 is free and open to everyone from high school students to Deepmind.

    Free Participation in Round 2 is offered to top performers in Round 1.

  • The pilot is a ‘dress rehearsal’ of the tournament. Participants in the pilot will have the opportunity to provide feedback and suggestions on the timeline, logistics, and scoring.

  • Sequences in the in-silico phase may have been patented previously.


    The submitted sequences will be shared freely with the broader community.

    All methods belong to the teams.

    We ask teams to not knowingly infringe on IP.

Still have more questions?

Email us at tournament@alignbio.org.

Supported by

SPONSORS

COLLABORATORS

DATASET CONTRIBUTORS